采用Monolix 软件发表的部分参考文献汇总（2019-2024.6）

凡默谷技术部挑选了2019年-2024年6月，全球采用群体药代动力学建模软件Monolix发表或涉及Monolix的部分应用文章。希望对您的业务或专业学习有所帮助。

庆大霉素在急性淋巴细胞白血病儿科患者与非肿瘤患者的群体药代动力学比较

Population pharmacokinetics of gentamicin in acute lymphoblastic leukemia pediatric patients compared to non-oncology patients

Hisham S. Abou-Auda, Fatimah Alotaibi, Sary Alsanea,c Abdulrahman Alwhaibi, Mohammed M. Almutairi, Ziyad Alrabiah, Abdullah Alsultan, and Majed Al Jeraisy. Saudi Pharm J. 2024 May; 32(5): 102060.

阿达木单抗和依那西普生物类似物在类风湿关节炎患者的群体药代动力学分析和替代给药方案模拟

Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis

Stephanie F. Ling, ORCID, Kayode Ogungbenro, Adam S. Darwich ORCID,Amirah Binti Mohammad Ariff 1,Nisha Nair, James Bluett, ORCID, Ann W. Morgan ,John D. Isaacs,Anthony G. Wilson ORCID, Kimme L. Hyrich, Anne Barton ORCID and Darren Plant. Pharmaceutics. 2024, 16(6), 702

基于药代动力学和使用唾液评估和优化儿科给药剂量—案例研究

Pharmacokinetics-Based Pediatric Dose Evaluation and Optimization Using Saliva – A Case Study

Marion Anliker-Ort , Frédérique Rodieux , Victoria C Ziesenitz , Andrew Atkinson , Julia A Bielicki , Thomas O Erb , Nicolas Gürtler , Stefan Holland-Cunz , Urs Duthaler , Deborah Rudin , Manuel Haschke , John van den Anker , Marc Pfister , Verena Gotta. J Clin Pharmacol. 2024 Jul; 64(7):810-819.

2岁以下婴儿口服螺内酯的药代动力学

Pharmacokinetics of oral spironolactone in infants up to 2 years of age

Jana Lass, Stephanie Leroux, Lenne-Triin Kõrgvee, Heili Varendi, Karin Kipper, Kalev Takkis, Rudolf Aro, Tuuli Metsvaht, Kersti Oselin, Marc Pfister, Hiie Soeorg, Johannes van den Anker & Irja Lutsar. European Journal of Clinical Pharmacology. Volume 80, pages 239–248, (2024)

氨己烯酸Vigabatrin在癫痫痉挛儿科患者的剂量优化：群体药代动力学方法

Optimization of vigabatrin dosage in children with epileptic spasms: A population pharmacokinetic approach

Agathe Molimard , Frantz Foissac , Naïm Bouazza , Inès Gana , Sihem Benaboud , Léo Froelicher , Déborah Hirt , Saïk Urien , Isabelle Desguerre , Jean-Marc Treluyer , Nicole Chemaly , Rima Nabbout. Br J Clin Pharmacol. 2024 Apr 25

低剂量氯胺酮在清醒狗的立体选择性药代动力学

Stereoselective Pharmacokinetics of Ketamine Administered at a Low Dose in Awake Dogs

Gwenda Pargätzi, Alessandra Bergadano, Claudia Spadavecchia, Regula Theurillat, Wolfgang Thormann, Olivier L Levionnois. Animals (Basel). 2024 Apr; 14(7): 1012

达沙替尼Dasatinib在健康受试者中的群体药代动力学

Population Pharmacokinetics of Dasatinib in Healthy Subjects

Walaa B. Hassouneh, Mutasim A. Al-Ghazawi, Mohammad I. Saleh and Naji Najib. Pharmaceuticals 2024, 17(6), 671

使用稀疏数据的基于药代动力学的生物等效性研究方法：模型选择还是模型平均？

Model-based bioequivalence approach for sparse pharmacokinetic bioequivalence studies: Model selection or model averaging?

Morgane Philipp, Adrien Tessier, Mark Donnelly, Lanyan Fang, Kairui Feng, Liang Zhao, Stella Grosser, Guoying Sun, Wanjie Sun, France Mentré, Julie Bertrand. Stat Med. 2024 Jun 7

酪氨酸激酶抑制剂在非小细胞肺癌细胞系中的体外PK/PD 建模

In vitro PK/PD modeling of tyrosine kinase inhibitors in non-small cell lung cancer cell lines

Linda Wanika, Neil D Evans, Martin Johnson, Helen Tomkinson, Michael J Chappell. Clin Transl Sci. 2024 Mar;17(3):e13714

咯酸氨丁三醇持续输注新制剂(NTM-001) 在健康受试者的随机对照试验

A Randomized Controlled Trial of a Novel Formulation of Ketorolac Tromethamine for Continuous Infusion (NTM-001) in Healthy Volunteers

oseph V Pergolizzi Jr, Amanjot Batra, William K Schmidt. Adv Ther. 2024 Feb;41(2):659-671.

评估美罗培南在儿科患者中的PK-PD达标情况

Evaluation of pharmacokinetic pharmacodynamic target attainment of meropenem in pediatric patients

Abdullah Alsultan, Maram R. Aldawsari, Nujood Khaled Alturaiq, Saeed Ali Syed, Abdulaziz Alsubai, Zeyad Kurdee, Sarah Alsubaie, Saeed Alqahtani,Manal Abouelkheir. Pediatr Neonatol. 2024 Jan 3: S1875-9572(23)00245-0

万古霉素在苏丹国成年肾功能不全患者的群体药代动力学和基于模型的剂量优化

Population Pharmacokinetics and Model-Based Dose Optimization of Vancomycin in Sudanese Adult Patients with Renal Impairment

Khalid Altigani Ahmed, Alnada Ibrahim, Daniel Gonzalez, and Abubakr O Nur. Drug Des Devel Ther. 2024; 18: 81–95.

新型恩格列净 L-脯氨酸制剂与其传统制剂的比较：通过一项在健康受试者的群体药代动力学研究

A Population Pharmacokinetic Study to Compare a Novel Empagliflozin L-Proline Formulation with Its Conventional Formulation in Healthy Subjects

Xu Jiang, Kyung-Sang Yu , Dong Hyuk Nam 4, Jaeseong Oh. Pharmaceuticals (Basel). 2024 Apr 18;17(4):522. doi: 10.3390/ph17040522.

评估影响利福平在高加索健康受试者药代动力学的体重相关协变量

Assessment of body mass-related covariates for rifampicin pharmacokinetics in healthy Caucasian volunteers

Muhammad Bilal, Sami Ullah, Ulrich Jaehde, Christina Trueck, Dario Zaremba, Bertil Wachall, Manfred Wargenau, Bernhard Scheidel, Martin H J Wiesen, Malaz Gazzaz, Chunli Chen, Sören Büsker, Uwe Fuhr, Max Taubert, Charalambos Dokos. Eur J Clin Pharmacol. 2024 May 9. doi: 10.1007/s00228-024-03697-3

在肥胖的重症患者中开展肥胖/重症患者万古霉素的群体药代动力学模型的外部验证

External Validation of Obese/Critically Ill Vancomycin Population Pharmacokinetic Models in Critically Ill Patients Who Are Obese

Abdullah Alsultan, Shereen A Dasuqi, Abdullah Almohaizeie, Abdullah Aljutayli, Fadi Aljamaan, Rasha A Omran, Abdulaziz Alolayan, Mohammed A Hamad, Haifa Alotaibi, Sarah Altamimi, Sarah S Alghanem. J Clin Pharmacol. 2024 Mar;64(3):353-361.

霉酚酸在系统性红斑狼疮儿童患者的有限采样策略和群体药代动力学模型：双伽马吸收模型与SAEM算法的应用

Limited sampling strategy and population pharmacokinetic model of mycophenolic acid in pediatric patients with systemic lupus erythematosus: application of a double gamma absorption model with SAEM algorithm

Kévin Koloskoff , Sylvain Benito, Lucie Chambon, Frédéric Dayan, Pierre Marquet, Evelyne Jacqz-Aigrain, Jean-Baptiste Woillard. Eur J Clin Pharmacol. 2024 Jan;80(1):83-92.

肝素在静脉-动脉体外膜氧合中给药方案的优化：药代动力学分析

Heparin Dosing Regimen Optimization in Veno-Arterial Extracorporeal Membrane Oxygenation: A Pharmacokinetic Analysis

Julien Lanoiselée, Jérémy Mourer, Marie Jungling, Serge Molliex, Lise Thellier, Julien Tabareau, Emmanuelle Jeanpierre, Emmanuel Robin, Sophie Susen, Benoit Tavernier, André Vincentelli, Edouard Ollier and Mouhamed Djahoum Moussa. Pharmaceutics. 2024, 16(6), 770

桥接APX3330 的群体药代动力学和半机制性吸收模型

Bridging population pharmacokinetic and semimechanistic absorption modeling of APX3330

Larissa L Silva, Robert E Stratford, Richard Messmann, Mark R Kelley, Sara K Quinney. CPT Pharmacometrics Syst Pharmacol. 2024 Jan;13(1):106-117

拉沙洛西在产蛋母鸡单次静脉注射和嗉囊内注射后的群体药代动力学和绝对口服生物利用度

Population Pharmacokinetics and Absolute Oral Bioavailability of Lasalocid after Single Intravenous and Intracrop Administration in Laying Hens

A Bello, J P Mochel, P Jajor, K Bobrek, M Świtała, B Poźniak. J Agric Food Chem. 2024 Jun 12;72(23):13348-13359

莫西菌素Moxidectin作为研究药代动力学体内内部的候选物，已在同时进行组织笼和超滤液收集中得到验证

Moxidectin is a candidate for use as an in vivo internal standard in pharmacokinetic studies, as demonstrated with use in simultaneous tissue cage and ultrafiltration fluid collection

Richard Munn, Ted Whittem. Front Vet Sci. 2024 Jan 16:11:1332974

通过诱导期间的英夫利昔单抗浓度预测炎症性肠病的缓解时间和控制疾病的持续时间

Forecasted infliximab concentrations during induction predict time to remission and sustained disease control of inflammatory bowel disease

Severine Vermeire, Marla C Dubinsky, Shervin Rabizadeh, John C Panetta, Elisabeth A Spencer, Erwin Dreesen, Geert D'Haens, Thierry Dervieux, David Laharie. Clin Res Hepatol Gastroenterol. 2024 Jun;48(6):102374.

基于模型预测伊立替康癌症患者诱发4级中性粒细胞减少症：在模型中纳入种系遗传因素的影响

Model-Based Prediction of Irinotecan-Induced Grade 4 Neutropenia in Cancer Patients: Influence of Incorporating Germline Genetic Factors in the Model

Spinel Karas, Ron H J Mathijssen, Ron H N van Schaik, Alan Forrest, Tim Wiltshire, Robert R Bies, Federico Innocenti. Clin Pharmacol Ther. 2024 May;115(5):1162-1174

通过群体动力学模型引导氯氮平剂量的选择：年龄、性别、种族、体重和吸烟状况的影响

A population pharmacokinetic model to guide clozapine dose selection, based on age, sex, ethnicity, body weight and smoking status

Suzanne Reeves, Julie Bertrand, Stephen John Obee, Samora Hunter, Robert Howard, Robert James Flanagan. British Journal of Clinical Pharmacology. February 2023. Volume 90, Issue1

与年龄相关性黄斑变性患者抗 VEGF 治疗的群体药代动力学/药效学模型

Towards a population pharmacokinetic/pharmacodynamic model of anti-VEGF therapy in patients with age-related macular degeneration

Eva M Del Amo, Paul N Bishop, Pere Godia, Leon Aarons. Eur J Pharm Biopharm. 2023 Jul:188:78-88

他克莫司在心脏移植成年患者中的群体药代动力学

Tacrolimus population pharmacokinetics in adult heart transplant patients

Adrien Paschier, Alexandre Destere, Caroline Monchaud, Marc Labriffe, Pierre Marquet, Jean-Baptiste Woillard. Br J Clin Pharmacol. 2023 Dec;89(12):3584-3595

用群体药代动力学模型研究儿童肾移植患者的肾功能对霉酚酸总清除率的显著影响

Significant Effects of Renal Function on Mycophenolic Acid Total Clearance in Pediatric Kidney Transplant Recipients with Population Pharmacokinetic Modeling

Yan Rong, Jenny Wichart, Lorraine Hamiwka, Tony K L Kiang. Clin Pharmacokinet. 2023 Sep;62(9):1289-1303

游离浓度和总浓度的达芦那韦与利托那韦在青少年中的同步PK建模：SMILE 试验的一项子研究

Simultaneous pharmacokinetic modeling of unbound and total darunavir with ritonavir in adolescents: a substudy of the SMILE trial

Abdalla S, Compagnucci A, Riault Y, Chan KM, Bamford A, Nolan A, Ramos TJ, Constant V, Nguyen T, Zheng Y, Tréluyer J, Froelicher-Bournaud L, Neveux N, Saidi Y, Cressey RT, Hirt D on behalf of the SMILE study group. Antimicrobial Agents and Chemotherapy. December 2023 Vol. 68, No. 2

三培非司亭Tripegfilgrastim在儿童患者化疗后的半机制性药代动力学-药效学模型

Semimechanistic pharmacokinetic-pharmacodynamic model of tripegfilgrastim for pediatric patients after chemotherapy

Soyoung Lee, Kyung Taek Hong, In-Jin Jang, Kyung-Sang Yu, Hyoung Jin Kang, Jaeseong Oh. CPT Pharmacometrics Syst Pharmacol. 2023 Sep;12(9):1319-1334

使用I期临床研究评估甲磺酸卡莫司他Camostat及其主要代谢产物的安全性和群体药代动力学

Safety Evaluation and Population Pharmacokinetics of Camostat Mesylate and Its Major Metabolites Using a Phase I Study

Gwanyoung Kim, Hyun-Ki Moon, Taeheon Kim, So-Hye Yun, Hwi-Yeol Yun, Jang Hee Hong, Dae-Duk Kim. Pharmaceutics. 2023 Sep 21;15(9):2357.

采用随机、开放标签、临床2a期研究，评估青蒿素对非洲无并发症恶性疟原虫疟疾患者的临床和杀寄生虫活性的贡献

Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria

Adama Gansane, Moussa Lingani, Adoke Yeka, Alain Nahum, Marielle Bouyou-Akotet, Ghyslain Mombo-Ngoma , Grace Kaguthi , Catalina Barceló, Bart Laurijssens, Cathy Cantalloube , Fiona Macintyre, Elhadj Djeriou, Andreas Jessel, Raphaël Bejuit, Helen Demarest, Anne Claire Marrast , Siaka Debe, Halidou Tinto, Afizi Kibuuka, Diolinda Nahum, Denise Patricia Mawili-Mboumba, Rella Zoleko-Manego, Irene Mugenya, Frederick Olewe, Stephan Duparc, Bernhards Ogutu. Clinical Trial Malar J. 2023 Jan 3; 22(1):2.

美罗培南在接受自动腹膜透析患者的群体药代动力学

Population pharmacokinetics of meropenem in patients undergoing automated peritoneal dialysis

Sami Ullah, Martin Ursli, Uwe Fuhr, Martin Wiesholzer, Manuel Kussmann, Wolfgang Poeppl, Markus Zeitlinger , Max Taubert. Perit Dial Int. 2023 Sep;43(5):402-410.

静脉输注的乙酰氨基酚及其代谢物在重症成年患者的群体药代动力学建模及剂量优化

Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults

Kannan Sridharan, Mwila Mulubwa, Ali Mohamed Qader. Eur J Drug Metab Pharmacokinet. 2023 Sep;48(5):531-540

基于真实世界数据的先验信息建立阿达木单抗群体药代动力学模型

Population Pharmacokinetic Model of Adalimumab Based on Prior Information Using Real World Data

Silvia Marquez-Megias, Ricardo Nalda-Molina , Patricio Más-Serrano, Amelia Ramon-Lopez. Biomedicines. 2023 Oct 18;11(10):2822.

咪达唑仑在儿科手术中的药代动力学-药效学建模

Pharmacokinetic–Pharmacodynamic Modeling of Midazolam in Pediatric Surgery

Carmen Flores-Pérez, Luis Alfonso Moreno-Rocha, Juan Luis Chávez-Pacheco, Norma Angélica Noguez-Méndez, Janett Flores-Pérez, Delfina Ortiz-Marmolejo and Lina Andrea Sarmiento-Argüello. Pharmaceutics. 2023 Nov; 15(11): 2565

痛风患者服用酸樱桃汁后花青素的药代动力学和药效学

Pharmacokinetics and Pharmacodynamics of Anthocyanins after Administration of Tart Cherry Juice to Individuals with Gout

Luigi Brunetti, Lujing Wang, Andrew Wassef, Yongjia Gong, Anita Brinker, Brian Buckley, Peter E Lipsky, Patricia Ondar, George Poiani, Liping Zhao, Ah-Ng Kong 1, Naomi Schlesinger. Mol Nutr Food Res. 2023 May;67(9):e2200550

杜氏肌营养不良症临床试验的磁共振生物标志物和临床结果测量的多变量建模

Multivariate modeling of magnetic resonance biomarkers and clinical outcome measures for Duchenne muscular dystrophy clinical trials

Sarah Kim, Rebecca J Willcocks, Michael J Daniels, Juan Francisco Morales, Deok Yong Yoon, William T Triplett, Alison M Barnard, Daniela J Conrado, Varun Aggarwal, Ramona Belfiore-Oshan , Terina N Martinez, Glenn A Walter, William D Rooney, Krista Vandenborne. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1437-1449.

通过模型的模拟支持艾萨妥昔单抗Isatuximab 单独或与地塞米松联合用于治疗日本患者复发/难治性多发性骨髓瘤的申报获批

Model-based simulation to support the approval of isatuximab alone or with dexamethasone for the treatment of relapsed/refractory multiple myeloma in Japanese patients

Hoai-Thu Thai, Kimiko Koiwai, Yoshihisa Shitara, Hirotaka Kazama, Jean-Baptiste Fau, Dorothée Semiond, Christine Veyrat-Follet. CPT Pharmacometrics Syst Pharmacol. 2023 Dec;12(12):1846-1858.

基于模型评估食物和胃酸减少剂对新型cereblonE3 泛素连接酶调节活性分子mezigdomide (CC-92480) 口服吸收的影响

Model based assessment of food and acid reducing agent effects on oral absorption of mezigdomide (CC-92480), a novel cereblon E3 ligase modulator

Fan Wu, Liangang Liu, Allison Gaudy, Xiaomin Wang, Leon Carayannopoulos, Michael Pourdehnad, Manisha Lamba. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1473-1484

肾功能是高剂量左旋肉碱在脓毒症休克患者药代动力学响应的关键驱动因素

Kidney function as a key driver of the pharmacokinetic response to high-dose L-carnitine in septic shock

Theodore S Jennaro, Michael A Puskarich, Thomas L Flott, Laura A McLellan, Alan E Jones, Manjunath P Pai, Kathleen A Stringer. Pharmacotherapy. 2023 Dec;43(12):1240-1250

联合使用群体药代动力学和机器学习来优化儿科人群的抗癫痫治疗

Joint use of population pharmacokinetics and machine learning for optimizing antiepileptic treatment in pediatric population

Ivana Damnjanović, Nastia Tsyplakova, Nikola Stefanović, Tatjana Tošić, Aleksandra Catić-Đorđević, Vangelis Karalis. Ther Adv Drug Saf. 2023 Jun 21:14:20420986231181337.

采用 HPLC-UV对人血浆中的盐酸二甲双胍进行生物分析方法验证，从而开展初步的群体的药代动力学建模研究

Bioanalytical Method Validation of Metformin Hydrochloride in Human Plasma by HPLC-UV for Preliminary Population-Based Pharmacokinetic Modeling Study

Dimas Adhi Pradana, Erna Kristin, Akhmad Kharis Nugroho, Dwi Aris Agung Nugrahaningsih, Mustofa Mustofa, Ari Wibowo. Indonesian Journal of Chemistry August 2023 23(4):937

地塞米松对 COVID-19 患者的抗炎作用：对群体 PK/PD 建模与模拟进行转化

Anti-inflammatory effects of dexamethasone in COVID-19 patients: Translational population PK/PD modeling and simulation

Artur Świerczek , William J Jusko. Clin Transl Sci. 2023 Sep;16(9):1667-1679.

药物监测方法驱动的一线治疗药物英夫利昔单抗在治疗儿童急性肠道和肝脏GVHD方面的优势：一项前瞻性、单中心研究

Advantage of First-Line Therapeutic Drug Monitoring-Driven Use of Infliximab for Treating Acute Intestinal and Liver GVHD in Children: A Prospective, Single-Center Study

Natalia Maximova, Daniela Nisticò, Guglielmo Riccio, Alessandra Maestro, Egidio Barbi, Barbara Faganel Kotnik, Annalisa Marcuzzi, Erika Rimondi, Antonello Di Paolo. Cancers (Basel). 2023 Jul 13;15(14):3605.

单核苷酸变异和营养状况对阿霉素在白血病儿童患者的群体药代动力学和心脏毒性的影响

Impact of single-nucleotide variants and nutritional status on population pharmacokinetics of Doxorubicin, and its effect on cardiotoxicity in children with leukemia

Jesús Alonso Gándara-Mireles, Ismael Lares-Asseff, Elio Aarón Reyes Espinoza, Ignacio Villanueva Fierro, Verónica Loera Castañeda, Lourdes Patricia Cordova Hurtado, Carla Díaz González, Leslie Patrón Romero, Horacio Almanza Reyes. J Oncol Pharm Pract. 2023 Sep;29(6):1290-1305

在有无种族因素影响下估算药物的肾小球滤过率：胱抑素C与血清肌酐

Estimated glomerular filtration rate with and without race for drug dosing: Cystatin C vs. serum creatinine

Hyun Gi Yun, Andrew J F Smith, Kenneth C DeBacker, Manjunath P Pai. Br J Clin Pharmacol. 2023 Mar;89(3):1207-1210.

使用已发表的瑞德西韦及其主要代谢物在健康受试者的平均值，来建立对应的群体药代动力学模型

A population pharmacokinetic model of remdesivir and its major metabolites based on published mean values from healthy subjects

Ahmed Abouellil, Muhammad Bilal, Max Taubert, Uwe Fuhr. Naunyn Schmiedebergs Arch Pharmacol. 2023 Jan;396(1):73-82

采用甲氨蝶呤在尿液的药代动力学新模型评估类风湿关节炎患者的依从性

A new pharmacokinetic model of urinary methotrexate to assess adherence in rheumatoid arthritis

Marion Geoffroy, Claire Gozalo, Céline Konecki, Loic Pauvele, Ambre Hittinger, Noemie Theate, Catherine Feliu, Jean Hugues Salmon, Zoubir Djerada. Biomed Pharmacother. 2023 Dec: 168:115620

虚拟临床试验：一种用于预测非小细胞肺癌患者在接受帕博利珠单抗Pembrolizumab

治疗后可能获益的工具

Virtual clinical trials: A tool for predicting patients who may benefit from treatment beyond progression with pembrolizumab in non-small cell lung cancer

Timothy Qi, Yanguang Cao. CPT Pharmacometrics Syst Pharmacol. 2023 Feb;12(2):236-249

基于模型引导Sabatolimab单抗 (MBG453) 的药物开发，指导骨髓增生异常综合征/急性髓系白血病和实体瘤患者的剂量选择

Sabatolimab (MBG453) model-informed drug development for dose selection in patients with myelodysplastic syndrome/acute myeloid leukemia and solid tumors

Siyan Xu, Na Zhang, Mikael L Rinne, Haiying Sun, Andrew M Stein. CPT Pharmacometrics Syst Pharmacol. 2023 Nov;12(11):1653-1665

接受肾移植的儿科患者口服泼尼松后的泼尼松龙药代动力学

Prednisolone pharmacokinetics after oral prednisone administration in paediatric patients with kidney transplant

Camille de Truchis, Naïm Bouazza, Frantz Foissac, Marina Charbit, Laurène Dehoux, Gabrielle Lui, Mégane Ribot, Nelly Briand, Yi Zheng, Jean-Marc Tréluyer, Olivia Boyer. Br J Clin Pharmacol. 2023 May;89(5):1532-1540

头孢地尔Cefiderocol在危重患者的总体和游离型药物的药代动力学

Total and Unbound Pharmacokinetics of Cefiderocol in Critically Ill Patients

Noël Zahr, Saik Urien, Benoit Llopis, Gaëlle Noé, Nadine Tissot, Kevin Bihan, Helga Junot ,Clémence Marin, Bochra Mansour, Charles-Edouard Luyt, Alexandre Bleibtreu and Christian Funck-Brentano. Pharmaceutics. 2022 Dec; 14(12): 2786.

避开肾功能不全的住院患者减少阿莫西林的给药剂量，以避免药物的体内暴露不足

Steering Away from Current Amoxicillin Dose Reductions in Hospitalized Patients with Impaired Kidney Function to Avoid Subtherapeutic Drug Exposure

Cornelis Smit , Swapnoleena Sen, Elodie von Dach, Abderrahim Karmime, Pierre Lescuyer, David Tonoli, Julia Bielicki, Angela Huttner, Marc Pfister. Antibiotics (Basel). 2022 Sep 2;11(9):1190.

利伐沙班在伊朗患者的群体药代动力学和药效学建模

Rivaroxaban population pharmacokinetic and pharmacodynamic modeling in Iranian patients

Tayebeh Esmaeili, Mahmood Rezaee, Morteza Abdar Esfahani, Azadeh Davoudian, Dariush Omidfar, Saeed Rezaee. J Clin Pharm Ther. 2022 Aug;47(8):1284-1292

酪氨酸激酶抑制剂Asciminib在治疗费城染色体阳性的慢性粒细胞白血病慢性期和急性期的群体药代动力学

Population Pharmacokinetics of Asciminib in Tyrosine Kinase Inhibitor-Treated Patients with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic and Acute Phases

Ying Fei Li , Francois Pierre Combes, Matthias Hoch, Sebastien Lorenzo, Sherwin K B Sy, Yu-Yun Ho. Clin Pharmacokinet. 2022 Oct;61(10):1393-1403.

纳布啡Nalbuphine鼻腔内和静脉给药后的定量药理学分析，以优化婴儿的疼痛管理

Pharmacometric Analysis of Intranasal and Intravenous Nalbuphine to Optimize Pain Management in Infants

Miriam Pfiffner, Eva Berger-Olah, Priska Vonbach, Marc Pfister, Verena Gotta. Front Pediatr. 2022 Mar 2:10:837492.

奈必洛尔的计算机模拟药代动力学研究后的新数据：重点关注年轻患者和给药方案

New Data for Nebivolol after In Silico PK Study: Focus on Young Patients and Dosage Regimen

Lara Marques, Bárbara Costa,and Nuno Vale. Pharmaceutics. 2022 Sep; 14(9): 1911.

基于纵向模型的肺功能反应荟萃分析，以支持中国哮喘患者 III 期临床研究设计

Longitudinal Model-Based Meta-Analysis of Lung Function Response to Support Phase III Study Design in Chinese Patients With Asthma

Shuying Yang, Monica Simeoni, Misba Beerahee. Clin Pharmacol Ther. 2022 Jun;111(6):1286-1295.

优化莫西克丁治疗粪类圆线虫感染的给药剂量：来自定量药理学建模的见解

Optimizing moxidectin dosing for Strongyloides stercoralis infections: Insights from pharmacometric modeling

Daniela Hofmann, Cornelis Smit, Somphou Sayasone, Marc Pfister, Jennifer Keiser. Clin Transl Sci. 2022 Mar;15(3):700-708.

SAMBA：非线性混合效应模型中快速自动建立模型的新方法

SAMBA: A novel method for fast automatic model building in nonlinear mixed-effects models

Mélanie Prague, Marc Lavielle. CPT Pharmacometrics Syst Pharmacol. 2022 Feb;11(2):161-172.

使用具有预测力的定量药理学算法来加强围产期护理-应用于新生儿黄疸

Leveraging Predictive Pharmacometrics-Based Algorithms to Enhance Perinatal Care-Application to Neonatal Jaundice

Gilbert Koch, Melanie Wilbaux, Severin Kasser, Kai Schumacher, Britta Steffens, Sven Wellmann, Marc Pfister. Front Pharmacol. 2022 Aug 11:13:842548.

基于竞争风险的联合建模：应用于重症监护病房脓毒症患者生存预测，并采用每日序贯器官衰竭评分进行评估

Joint modeling under competing risks: Application to survival prediction in patients admitted in Intensive Care Unit for sepsis with daily Sequential Organ Failure Assessment score assessments

Alexandra Lavalley-Morelle,Jean-François Timsit, France Mentré, Jimmy Mullaert, The OUTCOMEREA network. CPT Pharmacometrics Syst Pharmacol. 2022 Nov; 11(11): 1472–1484.

大剂量替加环素在呼吸机相关性肺炎患者的肺内药代动力学

Intrapulmonary pharmacokinetics of high doses of tigecycline in patients with ventilator-associated pneumonia

G Dimopoulos, M P Almyroudi, I Kapralos, O Apostolopoulou, A Flevari, D P Nicolau, A Dokoumetzidis. Int J Antimicrob Agents. 2022 Jan;59(1):106487

CYP3A5 和 CYP3A4 基因对芬太尼在儿童人群中药代动力学的影响

Effect of CYP3A5 and CYP3A4 Genetic Variants on Fentanyl Pharmacokinetics in a Pediatric Population

Michael L Williams, Prince J Kannankeril, Joseph H Breeyear , Todd L Edwards, Sara L Van Driest, Leena Choi. Clin Pharmacol Ther. 2022 Apr;111(4):896-908.

明确年龄相关的变化对药物清除率的影响，对优化氨基糖苷类药物在囊性纤维化成年患者给药方案的重要性

Defining the Importance of Age-Related Changes in Drug Clearance to Optimizing Aminoglycoside Dosing Regimens for Adult Patients with Cystic Fibrosis

Roxane Rohani , Brian Hoff, Manu Jain, Alexander Philbrick, Sara Salama, Joanne F Cullina, Nathaniel J Rhodes. Eur J Drug Metab Pharmacokinet. 2022 Mar;47(2):199-209

首次治疗剂量的药物监测能否预测白消安在接受造血干细胞移植的儿科患者的稳态血药浓度-时间AUC?

Can First-Dose Therapeutic Drug Monitoring Predict the Steady State Area Under the Blood Concentration-Time Curve of Busulfan in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation?

Abdullah Alsultan, Ahmed A Albassam, Abdullah Alturki, Abdulrahman Alsultan, Mohammed Essa , Bader Almuzzaini, Salman Alfadhel. Front Pediatr. 2022 Apr 7:10:834773.

胺碘酮/N-去乙基胺碘酮在儿科患者的群体药代动力学

Amiodarone/N-desethylamiodarone population pharmacokinetics in paediatric patients

Amélia Lehnert, Frantz Foissac, Naïm Bouazza, Saïk Urien, Mehdi Oualha, Sylvain Renolleau, Claudio Barbanti, Anna Di Marzio, Damien Bonnet, Seef Abdalla, Yi Zheng, Jean-Marc Treluyer. Br J Clin Pharmacol. 2022 Dec;88(12):5369-5377.

转移性肾细胞癌患者舒尼替尼的自适应给药剂量研究：计算机模拟有助于更快地达到临床终点

Adaptive dosing of sunitinib in a metastatic renal cell carcinoma patient: when in silico modeling helps to go quicker to the point

Florent Ferrer, Jonathan Chauvin, Jean-Laurent Deville, Joseph Ciccolini. Cancer Chemother Pharmacol. 2022 Apr;89(4):565-569.

采用单贝叶斯估算评估碘海醇iohexol 在ICU、肝功能衰竭和肾移植患者的清除率

A single Bayesian estimator for iohexol clearance estimation in ICU, liver failure and renal transplant patients

Alexandre Destere, Charlotte Salmon Gandonnière, Anders Åsberg, Véronique Loustaud-Ratti , Paul Carrier , Stephan Ehrmann, Chantal Barin-Le Guellec, Pierre Marquet, Jean-Baptiste Woillard. Br J Clin Pharmacol. 2022 Jun;88(6):2793-2801.

晚期乳腺癌动力学与无进展生存期的联合建模：使用Amcenestrant 临床试验I-II 期的数据

Joint modeling of tumor dynamics and progression‐free survival in advanced breast cancer: Leveraging data from amcenestrant early phase I–II trials

Hoai‐Thu Thai,corresponding author Nadia Gaudel, Marc Cerou, Geraldine Ayral, Jean‐Baptiste Fau, Bernard Sebastien, Helgi van de Velde, Dorothée Semiond, and Christine Veyrat‐Follet. Br J Clin Pharmacol. 2022 May; 88(5): 2052–2064.

通过无偏相关检验的非线性混合效应模型进行协变量选择的新方法：COSSAC方法

A novel method based on unbiased correlations tests for covariate selection in nonlinear mixed effects models: The COSSAC approach

Géraldine Ayral, Jean-François Si Abdallah, Claude Magnard, Jonathan Chauvin. CPT Pharmacometrics Syst Pharmacol. 2021 Apr;10(4):318-329.

小鼠体内的维生素D水平不会引起地塞米松或达沙替尼与维生素的药物相互作用

Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice

Kavya Annu, Kazuto Yasuda, William V. Caufield, Burgess B. Freeman III, Erin G. Schuetz. PLoS One. 2021 Oct 20;16(10): e0258579.

使用群体 PK/PD 方法模拟凝血酶生成试验：对掺入TFPI 抗体的血友病A血浆样本进行评估

Use of population PK/PD approach to model the thrombin generation assay: assessment in haemophilia A plasma samples spiked by a TFPI antibody

Raphaël Crépin, Claire Morin, Aurélie Montmartin, Brigitte Tardy-Poncet, Pierre Chelle. J Pharmacokinet Pharmacodyn. 2021 Aug;48(4):563-580.

环磷酰胺及4-羟基环磷酰胺代谢物在自身免疫性肾小球肾炎患者的群体药代动力学

Population pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide metabolite in patients with autoimmune glomerulonephritis

Veatriki N Iliopoulou, Georgia Charkoftaki, Jennifer C Cooper, Aristides Dokoumetzidis, Melanie S Joy. J Pharm Pharmacol. 2021 Dec 7;73(12):1683-1692

卡培他滨及其代谢物在乳腺癌患者中的群体药代动力学和药效学模型

Population pharmacokinetic and pharmacodynamic modeling of capecitabine and its metabolites in breast cancer patients

Nastja Lunar, Marie-Christine Etienne-Grimaldi, Pauline Macaire, Fabienne Thomas, Florence Dalenc, Jean-Marc Ferrero, Xavier Pivot, Gérard Milano, Bernard Royer, Antonin Schmitt. Cancer Chemother Pharmacol. 2021 Feb;87(2):229-239.

万古霉素在危重儿童患者中的群体药代动力学及剂量优化研究

Population Pharmacokinetics and Dose Optimization of Vancomycin in Critically Ill Children

Kannan Sridharan, Mohammad Yaseen Abbasi, Mwila Mulubwa. Eur J Drug Metab Pharmacokinet. 2021 Jul;46(4):539-546.

头孢他啶和亚胺培南在慢性阻塞性肺病急性加重期患者的群体药代动力学和剂量优化研究

Population Pharmacokinetics and Dose Optimization of Ceftazidime and Imipenem in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Thu-Minh Nguyen, Thu-Hue Ngo, Anh-Quan Truong, Dinh-Hoa Vu, Dinh-Chi Le, Ngan-Binh Vu, Tuyet-Nga Can, Hoang-Anh Nguyen, Thu-Phuong Phan, Françoise Van Bambeke, Céline Vidaillac, Quy-Chau Ngo. Pharmaceutics. 2021 Mar 27;13(4):456.

丙泊酚在新生儿和婴儿的群体药代动力学：妊娠和出生后年龄决定清除的成熟度

Population pharmacokinetics of propofol in neonates and infants: Gestational and postnatal age to determine clearance maturation

Louis Sandra, Anne Smits, Karel Allegaert, Johan Nicolaï, Pieter Annaert, Thomas Bouillon. Br J Clin Pharmacol. 2021 Apr; 87(4):2089-2097.

接受口服氟氯西林与丙磺舒治疗的患者中游离型氟氯西林的群体药代动力学

Population pharmacokinetics of free flucloxacillin in patients treated with oral flucloxacillin plus probenecid

Philip G Drennan, Jared K Green, Sharon J Gardiner, Sarah C L Metcalf, Carl M J Kirkpatrick, Richard J Everts, Mei Zhang, Stephen T Chambers. Br J Clin Pharmacol. 2021 Dec;87(12): 4681-4690.

在危重患者中持续注射万古霉素的群体药代动力学及给药模拟

Population Pharmacokinetics and Dosing Simulation of Vancomycin Administered by Continuous Injection in Critically Ill Patient

Romain Garreau, Benoît Falquet, Lisa Mioux, Laurent Bourguignon, Tristan Ferry, Michel Tod, Florent Wallet, Arnaud Friggeri, Jean-Christophe Richard, Sylvain Goutelle. Antibiotics (Basel). 2021 Oct 9;10(10):1228

以抗体缺陷为主的患者静脉注射免疫球蛋白的群体药代动力学建模

Population pharmacokinetic modelling of intravenous immunoglobulin in patients with predominantly antibody deficiencies

Jian Lynn Lee, Shamin Mohd Saffian, Mohd Makmor-Bakry, Farida Islahudin, Hamidah Alias, Lokman Mohd Noh, Intan Hakimah Ismail, Noraida Mohamed Shah. Br J Clin Pharmacol. 2021 Jul;87(7):2956-2966.

使用 Breezhaler® 装置对哮喘患者进行联合治疗后茚达特罗/格隆铵/糠酸莫米松的群体药代动力学分析

Population Pharmacokinetic Analysis of Indacaterol/Glycopyrronium/Mometasone Furoate After Administration of Combination Therapies Using the Breezhaler® Device in Patients with Asthma

Christian Bartels, Monish Jain, Jing Yu, Hanns-Christian Tillmann, Soniya Vaidya. Eur J Drug Metab Pharmacokinet. 2021 Jul;46(4):487-504.

克唑替尼crizotinib在患有进行性/复发性高级别和弥漫性内在性脑桥胶质瘤的儿童中的群体药代动力学分析

Population pharmacokinetic analysis of crizotinib in children with progressive/recurrent high-grade and diffuse intrinsic pontine gliomas

Elizabeth G Gibson, Olivia Campagne, Nicholas S Selvo, Amar Gajjar, Clinton F Stewart. Cancer Chemother Pharmacol. 2021 Dec;88(6):1009-1020.

伊沙妥昔单抗isatuximab单独给药和联合给药治疗多发性骨髓瘤患者的PK/PD 模型分析，以指导给药方案的选择

PK/PD modeling analysis for dosing regimen selection of isatuximab as single agent and in combination therapy in patients with multiple myeloma

Kimiko Koiwai, Raouf El-Cheikh, Hoai-Thu Thai, Claire Brillac, Jean-Baptiste Fau, Christine Veyrat-Follet, Marie-Laure Risse, Helgi van de Velde, Dorothée Semiond, Laurent Nguyen. CPT Pharmacometrics Syst Pharmacol. 2021 Aug;10(8):928-940.

现实生活中接受帕布昔利布palbociclib治疗的中性粒细胞减少症患者的药代动力学/药效学模型研究

Pharmacokinetic/Pharmacodynamic Model of Neutropenia in Real-Life Palbociclib-Treated Patients

Alexandre Le Marouille, Emma Petit, Courèche Kaderbhaï, Isabelle Desmoulins, Audrey Hennequin, Didier Mayeur, Jean-David Fumet, Sylvain Ladoire, Zoé Tharin, Siavoshe Ayati, Silvia Ilie, Bernard Royer, Antonin Schmitt. Pharmaceutics. 2021 Oct 16;13(10):1708.

在早产儿出生后静脉注射扑热息痛（乙酰氨基酚）和动脉导管闭合的药代动力学研究

Pharmacokinetics of Intravenous Paracetamol (Acetaminophen) and Ductus Arteriosus Closure After Premature Birth

Naïm Bouazza , Jean-Marc Treluyer, Frantz Foissac, Saïk Urien, Outi Aikio, Jean-Christophe Roze , Mikko Hallman. Clin Pharmacol Ther. 2021 Oct;110(4):1087-1095.

使用仑伐替尼引起高血压的真实世界上市后监测数据进行药效学分析

Pharmacodynamic analysis of hypertension caused by lenvatinib using real-world postmarketing surveillance data

Yuki Otani, Hidefumi Kasai, Yusuke Tanigawara. CPT Pharmacometrics Syst Pharmacol. 2021 Mar;10(3):188-198.

通过非线性混合效应模型对长效甘精胰岛素100 U/mL 皮下吸收的个体间变异性进行建模

Modeling Between-Subject Variability in Subcutaneous Absorption of a Long-Acting Insulin Glargine 100 U/mL by a Nonlinear Mixed Effects Approach

Edoardo Faggionato, Michele Schiavon, Chiara Dalla Man. Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov:2021:4226-4229.

通过非线性混合效应模型对速效胰岛素类似物的皮下吸收的个体间变异性进行建模

Modeling Between-Subject Variability in Subcutaneous Absorption of a Fast-Acting Insulin Analogue by a Nonlinear Mixed Effects Approach

Edoardo Faggionato , Michele Schiavon , Chiara Dalla Man. Metabolites. 2021 Apr 12;11(4):235.

米卡芬净Micafungin在健康和脓毒症猪的群体PK分析：脓毒症猪模型能否预测脓毒症患者中的米卡芬净 PK？

Micafungin Population PK Analysis in Healthy and Septic Pigs: Can the Septic Porcine Model Predict the Micafungin PK in Septic Patients?

Nicolas Garbez Litaty C. Mbatchi · Guillaume Louart · Steven C. Wallis · Laurent Muller·Jeffrey Lipman · Jason A. Roberts · Jean‑Yves Lefrant · Claire Roger. Pharmaceutical Research November 2021 38(1)

评估羟氯喹在系统性红斑狼疮儿童患者的血药浓度和对应的疗效

Evaluation of Hydroxychloroquine Blood Concentrations and Effects in Childhood-Onset Systemic Lupus Erythematosus

Noël Zahr, Saik Urien, Christian Funck-Brentano, Hélène Vantomme, Nicolas Garcelon, Isabelle Melki, Margaux Boistault, Olivia Boyer, Brigitte Bader-Meunier. Pharmaceuticals (Basel). 2021 Mar 17;14(3):273.

氟喹诺酮类药物治疗骨关节感染的剂量调整工具的开发：Fluo-pop研究

Development of a dosing-adjustment tool for fluoroquinolones in osteoarticular infections: The Fluo-pop study

Florian Lemaitre, Fabien Fily, Jean-Baptiste Foulquier, Matthieu Revest, Vincent Jullien, Antoine Petitcollin, Pierre Tattevin, Camille Tron, Jean-Louis Polard, Marie-Clémence Verdier, Emmanuelle Comets, Denis Huten, Cédric Arvieux, Eric Bellissant, Bruno Laviolle. Biomed Pharmacother. 2021 Oct: 142:112053.

开发用于评估非线性混合效应模型的工具：npde 20年的经历

Developing Tools to Evaluate Non-linear Mixed Effect Models: 20 Years on the npde Adventure

Emmanuelle Comets and France Mentré. The AAPS Journal. May 2021 23(4):75

确定万古霉素的体内暴露目标和新生儿个体化给药建议：基于模型的精准给药

Determination of vancomycin exposure target and individualised dosing recommendations for neonates: model-informed precision dosing

Zhe Tang , Jing Guan , Jingjing Li , Yanxia Yu , Miao Qian , Jing Cao , Weiwei Shuai , Zheng Jiao. International Journal of Antimicrobial Agents. 57 (2021) 106300

比较三种拉米呋啶盖仑制剂在感染HIV的西非儿童患者中的疗效

Comparison of three galenic forms of lamivudine in young West African children living with Human Immunodeficiency Virus

Claire Pressiat, Evelyne Dainguy, Jean-Marc Tréluyer, Caroline Yonaba, Saik Urien, François Eboua, Frantz Foissac, Désiré Lucien Dahourou, Naïm Bouazza, Karen Malateste, Sophie Desmonde, Alain Pruvost, Valériane Leroy, Déborah Hirt, The Monod Anrs Study Group. Antivir Ther. 2021 Nov;26(6-8):134-140.

对比基于临床与基于模型的自适应给药策略：现实世界中接受舒尼替尼治疗的mRCC患者的回顾性比较

Clinical-Based vs. Model-Based Adaptive Dosing Strategy: Retrospective Comparison in Real-World mRCC Patients Treated with Sunitinib

Florent Ferrer, Jonathan Chauvin, Bénédicte DeVictor, Bruno Lacarelle, Jean-Laurent Deville, Joseph Ciccolini. Pharmaceuticals (Basel). 2021 May 24;14(6):494.

使用3期数据对 6 岁以上至 12 岁以下青少年和儿童进行 Dupilumab 的群体药代动力学的基础和协变量分析

Base and Covariate Population Pharmacokinetic Analyses of Dupilumab in Adolescents and Children ≥6 to <12 Years of Age Using Phase 3 Data

Pavel Kovalenko, Mohamed A Kamal, John D Davis, Nidal Huniti, Christine Xu, Ashish Bansal, Brad Shumel, A Thomas DiCioccio. Clin Pharmacol Drug Dev. 2021 Nov;10(11):1345-1357.

采用定量系统药理学方法确定激活JN信号通路是治疗难治性 HER2阳性乳腺癌的一种有希望的治疗策略

A quantitative systems pharmacological approach identified activation of JNK signaling pathway as a promising treatment strategy for refractory HER2 positive breast cancer

Yesenia L Franco, Vidya Ramakrishnan, Tanaya R Vaidya, Hardik Mody, Luis Perez, Sihem Ait-Oudhia. J Pharmacokinet Pharmacodyn. 2021 Apr;48(2):273-293.

头孢唑林在感染甲氧西林敏感金黄色葡萄球菌的危重病患儿中的群体药代动力学

Population pharmacokinetics of cefazolin in critically ill children infected with methicillin-sensitive Staphylococcus aureus

E Salvador, M Oualha, E Bille, A Beranger, F Moulin, S Benaboud, S Boujaafar, I Gana, S Urien, Y Zheng, J Toubiana, C Briand, O Bustarret, G Geslain, S Renolleau, J-M Treluyer, D Hirt. Clin Microbiol Infect. 2021 Mar;27(3):413-419.

丙磺舒和食物对氟氯西林在健康受试者药代动力学和药效学的影响

Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers

Richard J Everts, Ronald Begg, Sharon J Gardiner, Mei Zhang, John Turnidge, Stephen T Chambers, Evan J Begg. J Infect. 2020 Jan;80(1):42-53.

静脉和口服阿昔洛韦和口服伐昔洛韦在儿童人群的群体药代动力学研究，以优化给药方案

Population Pharmacokinetics of Intravenous and Oral Acyclovir and Oral Valacyclovir in Pediatric Population To Optimize Dosing Regimens

S Abdalla, C Briand, M Oualha , M Bendavid, A Béranger, S Benaboud, J-M Tréluyer , Y Zheng, C Capito, Z Demir, F Foissac, S Winter , I Gana , S Boujaafar , N Bouazza, D Hirt. Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01426-20.

接受复合阿莫西林-克拉维酸治疗的肥胖成人中的阿莫西林群体药代动力学分析和给药剂量模拟

Population pharmacokinetics and dosing simulations of amoxicillin in obese adults receiving co-amoxiclav

G Mellon, K Hammas, C Burdet, X Duval, C Carette, N El-Helali, L Massias, F Mentré, S Czernichow, A-C Crémieux. J Antimicrob Chemother. 2020 Dec 1;75(12):3611-3618.

使用药代动力学/药效学模型优化万古霉素在癌症患者的给药方案

Optimization of Vancomycin Dosing Regimen in Cancer Patients using Pharmacokinetic/ Pharmacodynamic Modeling

Saeed Alqahtani, Abdullah Almatrafi , Norah Bin Aydan, Meshari Alqahtani, Faisal Alzamil, Abdullah Alsultan, Yousif Asiri. Pharmacotherapy. 2020 Dec;40(12):1192-1200.

Alpelisib在健康受试者的口服吸收、pH和食物影响的生理药代动力学建模，以推动其制剂处方的筛选

Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection

Monika Gajewska, Lars Blumenstein, Alexandros Kourentas, Martin Mueller-Zsigmondy, Sebastien Lorenzo, Angela Sinn, Maria Velinova, Tycho Heimbach. AAPS J. 2020 Oct 18;22(6):134

体外膜氧合对头孢洛扎/他唑巴坦药代动力学的影响：体外和体内研究

Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study

Camille Mané, Clément Delmas, Jean Porterie, Géraldine Jourdan, Patrick Verwaerde, Bertrand Marcheix, Didier Concordet, Bernard Georges, Stéphanie Ruiz, and Peggy Gandia. J Transl Med. 2020; 18: 213.

产后出血性剖宫产中氨甲环酸部分通过非尿液消除的假设：痕迹药代动力学试验研究，氨甲环酸在产科的药代动力学研究

Hypothesis for a partially non urinary elimination of tranexamic acid in haemorrhagic caesarean section: Traces pilot pharmacokinetic study: Pharmacokinetics of tranexamic acid in obstetrics

S Gilliot , A S Ducloy-Bouthors , B Hennart , F Loingeville , M Jeanne , G Lebuffe , P Odou. Eur J Pharm Sci. 2020 Oct 1:153:105486.

根据炎症-免疫疾病患者中的泼尼松龙总浓度预测游离型浓度的药代动力学

Free prednisolone pharmacokinetics predicted from total concentrations in patients with inflammatory - immunonologic conditions

Olivier Mangin , Yi Zheng, Naïm Bouazza, Frantz Foissac, Sihem Benaboud, Gabrielle Lui, Déborah Hirt, Luc Mouthon, Jean-Marc Tréluyer, Saïk Urien. Fundam Clin Pharmacol. 2020 Apr;34(2):270-278.

使用MonolixSuite实现高效的药代动力学建模工作流程：以瑞芬太尼为研究案例

Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil

Pauline Traynard, Géraldine Ayral, Monika Twarogowska, Jonathan Chauvin. CPT Pharmacometrics Syst Pharmacol. 2020 Apr;9(4):198-210.

伊沙妥昔单抗Isatuximab在复发/难治性多发性骨髓瘤患者中的药物-疾病相互作用和时间依赖性群体药代动力学

Drug-Disease Interaction and Time-Dependent Population Pharmacokinetics of Isatuximab in Relapsed/Refractory Multiple Myeloma Patients

Jean-Baptiste Fau, Raouf El-Cheikh, Claire Brillac, Kimiko Koiwai, Nathalie Mace, Frank Campana, Dorothee Semiond, Laurent Nguyen. CPT Pharmacometrics Syst Pharmacol. 2020 Nov;9(11):649-658.

治疗中断后HIV病毒载量反弹的经验模型与动态模型的比较

Comparison of empirical and dynamic models for HIV viral load rebound after treatment interruption

Ante Bing, Yuchen Hu , Melanie Prague , Alison L Hill , Jonathan Z Li , Ronald J Bosch , Victor De Gruttola , Rui Wang. Stat Commun Infect Dis. 2020;12(Suppl 1):20190021.

联合建模框架中纵向生物标志物和生存事件风险不确定性的贝叶斯个体动态预测：Stan、Monolix 和 NONMEM 之间的比较

Bayesian Individual Dynamic Predictions with Uncertainty of Longitudinal Biomarkers and Risks of Survival Events in a Joint Modelling Framework: a Comparison Between Stan, Monolix, and NONMEM

François Riglet , France Mentre , Christine Veyrat-Follet , Julie Bertrand. AAPS J. 2020 Feb 19; 22(2):50.

八因子VIII在重度血友病A患者的真实群体药代动力学建模：转换为缓释半衰期总是有意义的吗？

Real Life Population Pharmacokinetics Modelling of Eight Factors VIII in Patients with Severe Haemophilia A: Is It Always Relevant to Switch to an Extended Half-Life?

Quentin Allard, Zoubir Djerada, Claire Pouplard, Yohann Repessé, Dominique Desprez, Hubert Galinat, Birgit Frotscher, Claire Berger, Annie Harroche, Anne Ryman, Claire Flaujac, Pierre Chamouni, Benoît Guillet, Fabienne Volot, Jean Szymezak, Philippe Nguyen, Yoann Cazaubon. Pharmaceutics. 2020 Apr 21;12(4):380.

万古霉素在早产新生儿的药代动力学评估及给药方案优化

Assessment of Vancomycin Pharmacokinetics and Dose Regimen Optimisation in Preterm Neonates

Mwila Mulubwa, Heletje Aletta Griesel, Pierre Mugabo, Ricky Dippenaar, Lizelle van Wyk. Drugs R D. 2020 Jun;20(2):105-113.

选择性S1P1受体调节剂cenerimod在健康受试者和系统性红斑狼疮患者中的药代动力学和药效学建模

Modelling pharmacokinetics and pharmacodynamics of the selective S1P1 receptor modulator cenerimod in healthy subjects and systemic lupus erythematosus patients

Dominik Lott , Pierre-Eric Juif , Jasper Dingemanse , Andreas Krause. Br J Clin Pharmacol. 2020 Apr;86(4):791-800.

使用儿童烧伤患者的群体药代动力学表征芬太尼变异性

Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients

Kristin N Grimsrud, Kelly M Lima, Nam K Tran, Tina L Palmieri. J Burn Care Res. 2020 Jan 30;41(1):8-14.

口服溴必利的群体药代动力学：重点关注该药物的吸收过程

Population pharmacokinetics of orally administrated bromopride: Focus on the absorption process

Larissa Lachi-Silva, Aline B Barth, Gustavo Mendes Lima Santos, Malidi Ahamadi, Marcos Luciano Bruschi, Elza Kimura, Bibiana Verlindo de Araújo, Andréa Diniz. Eur J Pharm Sci. 2020 Jan 15:142:105081.

特立齐酮及其代谢物环丝氨酸在耐药结核病患者的稳态群体药代动力学研究

Steady-state population pharmacokinetics of terizidone and its metabolite cycloserine in patients with drug-resistant tuberculosis

Mwila Mulubwa , Pierre Mugabo. Br J Clin Pharmacol. 2019 Sep;85(9):1946-1956.

阿米卡星在儿童囊性纤维化患者的群体药代动力学

Population pharmacokinetics of amikacin in patients with pediatric cystic fibrosis

Paulo Caceres Guido, Mariel Perez, Alicia Halac, Mariela Ferrari, Manuel Ibarra, Nieves Licciardone, Claudio Castaños, Luis P Gravina, Cristina Jimenez, Facundo Garcia Bournissen, Paula Schaiquevich. Pediatr Pulmonol. 2019 Nov;54(11):1801-1810.

使用儿童和成人药代动力学数据推算维加巴特林治疗婴儿痉挛的最低有效剂量

Proposition of a Minimal Effective Dose of Vigabatrin for the Treatment of Infantile Spasms Using Pediatric and Adult Pharmacokinetic Data

Marwa Ounissi, Christelle Rodrigues, Hugues Bienayme, Paul Duhamel, G´erard Pons, Olivier Dulac, Rima Nabbout, Catherine Chiron, and Vincent Jullien. Pediatric Pharmacology. Vol 59 No 2 2019

吡嗪酰胺和吡嗪酸在耐多药结核病患者中的群体药代动力学建模

Population Pharmacokinetic Modelling of Pyrazinamide and Pyrazinoic Acid in Patients with Multi-Drug Resistant Tuberculosis

Pierre Mugabo, Mwila Mulubwa. European Journal of Drug Metabolism and Pharmacokinetics (2019) 44:519–530

使用非线性混合效应模型开展头孢噻呋钠在健康比格犬的药代动力学建模研究

Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs

Jianzhong Wang, Benjamin K. Schneider, Jiao Xue, Pan Sun, Jicheng Qiu, Jonathan P. Mochel, Xingyuan Cao. Front. Vet. Sci., 17 October 2019

速释口服他克莫司与霉酚酸酯联合给药用于治疗未使用过皮质类固醇的成年肾移植患者的群体药代动力学分析

Population Pharmacokinetic Analysis of Immediate-Release Oral Tacrolimus Co-administered with Mycophenolate Mofetil in Corticosteroid-Free Adult Kidney Transplant Recipients

Yan Rong, · Patrick Mayo, · Mary H. H. Ensom, · Tony K. L. Kiang. European Journal of Drug Metabolism and Pharmacokinetics (2019) 44:409–422

贝伐单抗和培美曲塞/顺铂在非小细胞肺癌患者中的最佳给药方案

Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer

Benjamin K. Schneider, Arnaud Boyer, Joseph Ciccolini, Fabrice Barlesi, Kenneth Wang, Sebastien Benzekry, Jonathan P. Mochel. CPT Pharmacometrics Syst. Pharmacol. (2019) 8, 577–586

姜黄素在健康受试者中调节抗氧化和表观遗传基因表达的药代动力学、药效学和PK-PD建模研究

Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers

David Cheng, Wenji Li, Lujing Wang, Tiffany Lin, George Poiani, Andrew Wassef, Rasika Hudlikar, Patricia Ondar, Luigi Brunetti, and Ah-Ng Kong. Mol. Pharmaceutics. 2019, 16, 5, 1881–1889

依折麦布及其结合代谢物的联合群体药代动力学模型的建立

Development of a joint population pharmacokinetic model of ezetimibe and its conjugated metabolite

Soulele K, Karalis V. European Journal of Pharmaceutical Sciences. Volume 128, 1 February 2019, Pages 18-26